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CP 673451

Catalog #: 5993
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CP 673451 | CAS No. 343787-29-1 | PDGF Receptor Inhibitors
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Description: Potent and selective PDGFR inhibitor

Chemical Name: 1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

CP 673451 is a potent and selective PDGFR inhibitor (IC50 values are 1 and 10 nM for PDGFR-β and -α respectively). Selective for PDGFR kinase over a range of related kinases. Inhibits PDGFR-β phosphorylation in glioblastoma xenografts and PDGF-induced angiogenesis in mice.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 673451 is reviewed on the Chemical Probes website.

Technical Data

M.Wt:
417.5
Formula:
C24H27N5O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
343787-29-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451.
    Roberts et al.
    Cancer Res., 2005;65:957
  2. TGF-&beta loaded exosome enhances ischemic wound healing in vitro and in vivo
    A Shi, J Li, X Qiu, M Sabbah, S Boroumand, TC Huang, C Zhao, A Terzic, A Behfar, SL Moran
    Theranostics, 2021;11(13):6616-6631.

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Citation for CP 673451

The citations listed below are publications that use Tocris products. Selected citations for CP 673451 include:

1 Citation: Showing 1 - 1

  1. A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane.
    Authors: Stacey M Et al.
    Cell Stem Cell  2021;28:315-330.e5

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