CP 809101 hydrochloride
Chemical Name: 2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride
Purity: ≥99%
Biological Activity
CP 809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50 values are 9.96, 7.19 and 6.81 for human 5-HT2C, 5-HT2B and 5-HT2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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5-HT(2C) Receptors in the Basolateral Amygdala and Dorsal Striatum Are a Novel Target for the Anxiolytic and Antidepressant Effects of Exercise.
Greenwood, Benjamin, Strong, Paul V, Loughridge, Alice B, Day, Heidi E, Clark, Peter J, Mika, Agnieszk, Hellwinkel, Justin E, Spence, Katie G, Fleshner, Monika
PLoS ONE, 2012;7(9):e46118. -
CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity.
Siuciak et al.
Neuropharmacology, 2007;52:279 -
Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.
Kalgutkar et al.
Drug Metab.Dispos., 2007;35:848 -
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive
Jensen et al.
J.Med.Chem., 2013;56:1211
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Citations for CP 809101 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CP 809101 hydrochloride include:
5 Citations: Showing 1 - 5
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Loss of GluN2D subunit results in social recognition deficit, social stress, 5-HT2C receptor dysfunction, and anhedonia in mice.
Authors: Yamamoto
Neuropharmacology 2017;112:188
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Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
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Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens.
Authors: Goda Et al.
Psychopharmacology (Berl) 2013;228:271
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First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors.
Authors: Schulz Et al.
Br J Pharmacol 2012;167:1480
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5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii.
Authors: Austgen Et al.
Oncotarget 2012;108:2292
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