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CP 93129 dihydrochloride

Catalog #: 1032
9 Citations Datasheet / COA / SDS
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CP 93129 dihydrochloride | CAS No. 879089-64-2 | 5-HT1B Receptor Agonists
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Description: 5-HT1B agonist

Chemical Name: 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride

Product Details
Citations (9)
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Biological Activity

CP 93129 dihydrochloride is a potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.

Technical Data

M.Wt:
288.18
Formula:
C12H13N3O.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Storage:
Desiccate at RT
CAS No:
879089-64-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor.
    Tung S, Hardy A, Wheeler M, Belsham D
    Endocrinology, 2012;153(10):4862-73.
  3. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253.
    Koe et al.
    Drug Development Research, 1992;26:241
  4. Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex.
    Hamid et al.
    J Neurosci., 2014;34:260
  5. Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats.
    Lee et al.
    Psychopharmacology, 1998;136:304

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Citations for CP 93129 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for CP 93129 dihydrochloride include:

9 Citations: Showing 1 - 9

  1. Modulation of Kalirin-7 Expression by Hippocampal CA1 5-HT1B Receptors in Spatial Memory Consolidation.
    Authors: Zhou Et al.
    Behav Brain Res  2019;356:148
  2. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
    Authors: Medrihan Et al.
    Neuron  2017;95:564
  3. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
    Authors: Hirono
    Neuropharmacology  2017;118:79
  4. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.
    Authors: Majeed Et al.
    Neural Plast  2016;2016:7291438
  5. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    Cereb Cortex  2015;3:e00103
  6. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.
    Authors: Guo and Rainnie
    Neuroscience  2010;165:1390
  7. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
    Authors: Watakabe Et al.
    Neuron  2009;19:1915
  8. Serotonin reciprocally regulates melanocortin neurons to modulate food intake.
    Authors: Heisler Et al.
    J Pharmacol Exp Ther  2006;51:239
  9. Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake.
    Authors: Rau Et al.
    Exp Ther Med  2006;318:676

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