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CP 96345

Catalog #: 2893
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2893/10
2893/50
CP 96345 | CAS No. 132746-60-2 | NK1 Receptor Antagonists
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Description: Potent and selective NK1 antagonist

Chemical Name: (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

CP 96345 is a potent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.

Technical Data

M.Wt:
412.57
Formula:
C28H32N2O
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
132746-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors
    A Taracanova, M Alevizos, A Karagkouni, Z Weng, E Norwitz, P Conti, SE Leeman, TC Theoharide
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
  2. A potent nonpeptide antagonist of the substance P (NK1) receptor.
    Snider et al.
    Science, 1991;251:435
  3. The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation.
    Lembeck et al.
    Br.J.Pharmacol., 1992;105:527
  4. Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury.
    Bang et al.
    J.Pharmacol.Exp.Ther., 2003;305:31

Product Datasheets

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Citation for CP 96345

The citations listed below are publications that use Tocris products. Selected citations for CP 96345 include:

1 Citation: Showing 1 - 1

  1. Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice.
    Authors: Silva Et al.
    Br J Pharmacol  2015;172:924

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