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CTPI 2

Catalog #: 7794 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7794/10
7794/50
CTPI 2 | CAS No. 68003-38-3 | Other Ion Pump/Transporter Inhibitors
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Description: Selective mitochondrial citrate transporter (SLC25A1) inhibitor

Chemical Name: 2-[[(4-Chloro-3-nitrophenyl)sulfonyl]amino]benzoic acid

Purity: ≥98%

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Biological Activity

CTPI 2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor with a KD of 3.5 μM. CTPI 2 inhibits the proliferation of H1299 cells in a SLC25A1-dependent manner. It also re-sensitizes T1, T2, and T4 cells to Cisplatin (Cat. No. 2251). CTPI 2 inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC). In high-fat diet fed mice CTPI 2 regulates glycolysis, prevents steatohepatitis and normalizes glucose tolerance and insulin sensitivity. CTPI 2 influences the inflammatory pathway by inhibiting IL-6 and TNFα production and M1 macrophage polarization.

Technical Data

M.Wt:
356.74
Formula:
C13H9ClN2O6S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
68003-38-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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