CU CPT 4a
Chemical Name: N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine
Purity: ≥98%
Biological Activity
CU CPT 4a is a selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Cell Type-Specific Responses of Peripheral Blood CD14-Positive Monocytes to Liposome-Encapsulated Immunostimulatory siRNA
Yukihiro Goda
Biol. Pharm. Bull., 2016;39(11):1859-1867. -
Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
Takemura et al.
Nat.Commun., 2014;18 -
Small-molecule inhibitors of the TLR3/dsRNA complex.
Cheng et al.
J.Am.Chem.Soc., 2011;133:3764
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Citations for CU CPT 4a
The citations listed below are publications that use Tocris products. Selected citations for CU CPT 4a include:
2 Citations: Showing 1 - 2
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Human macrophages utilize a wide range of pathogen recognition receptors to recognize Legionella pneumophila, including Toll-Like Receptor 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor
Authors: Grigoryeva Et al.
PLoS Pathog 2021;17:e1009781
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Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis.
Authors: Gerhard Et al.
JCI Insight 2020;5
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