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Curcumin

Catalog #: 2841
5 Citations 1 Review Datasheet / COA / SDS

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2841 has been discontinued.
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Curcumin | CAS No. 458-37-7 | Apoptosis Inducer Compounds
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Description: Antitumor, anti-inflammatory and antioxidant
Alternative Names: Diferuloylmethane

Chemical Name: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

Product Details
Citations (5)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Curcumin is an antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.

Technical Data

M.Wt:
368.38
Formula:
C21H20O6
Solubility:
Soluble to 10 mM in DMSO and to 5 mM in ethanol
Storage:
Store at -20°C
CAS No:
458-37-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antitumour, anti-invasion, and antimetastatic effects of curcumin.
    Kuttan et al.
    Adv.Exp.Med.Biol., 2007;595:173
  2. Neuroprotective effects of curcumin.
    Cole et al.
    Adv.Exp.Med.Biol., 2007;595:197
  3. Molecular targets of curcumin.
    Lin
    Adv.Exp.Med.Biol., 2007;595:227
  4. Cardioprotective effects of curcumin.
    Miriyala et al.
    Adv.Exp.Med.Biol., 2007;595:359
  5. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.
    Aggarwal and Sung
    TiPS, 2009;30:85

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Curcumin

The citations listed below are publications that use Tocris products. Selected citations for Curcumin include:

5 Citations: Showing 1 - 5

  1. CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II.
    Authors: Boija Et al.
    Mol Cell  2017;68:491
  2. Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin.
    Authors: Chang Et al.
    Sci Rep  2015;5:10256
  3. Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.
    Authors: Efthymiou Et al.
    J Neurosci  2015;4:230
  4. Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT.
    Authors: Chen Et al.
    Int J Mol Med  2012;30:1021
  5. Analgesic effects of intrathecal curcumin in the rat formalin test.
    Authors: Han Et al.
    Korean J Pain  2012;25:43252

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Curcumin treatment of mouse macrophages
By Anonymous on 09/24/2019
Species: Mouse

used at 10um to activate anti-oxidant response in mouse macrophages

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