CYM 50260
Chemical Name: 2-Chloro-3-[2-(2,4-dichlorophenoxy)ethoxy]-6-(fluoromethyl)pyridine
Purity: ≥98%
Biological Activity
CYM 50260 is a potent sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 = 45 nM). Displays no activity at other S1P receptor subtypes (S1P1-3 and S1P5) at concentrations up to 25 μM.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists.
Guerrero et al.
Bioorg.Med.Chem.Lett., 2011;22:537
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Citation for CYM 50260
The citations listed below are publications that use Tocris products. Selected citations for CYM 50260 include:
1 Citation: Showing 1 - 1
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Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2
Authors: Matsushima-Nishiwaki R Et al.
PLoS One 2018;13:e0209050
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