Cynomolgus Monkey IL-10 (BAA19132.1) VersaClone cDNA

Cynomolgus Monkey IL-10 (BAA19132.1) VersaClone cDNA Summary

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Background: IL-10

Interleukin-10 functions as an anti-inflammatory cytokine by inhibiting the expansion and activation of Th1 cells and Th17 cells and by promoting the development of M2 macrophages and regulatory T cells (Treg). Within a tumor microrenvironment, however, IL-10 can inhibit the expansion of both Treg and myeloid-derived suppressor cells (MDSC). IL-10 exerts protective effects including limiting tissue damage in arthritic inflammation and promoting muscle regeneration after injury, but it also contributes to the persistence of viral infections. IL-10 signals through a receptor complex composed of IL-10 R alpha and IL-10 R beta. IL-10 R beta additionally associates with IL-20 R alpha, IL-22 R alpha 1, or IL-28 R alpha to form the receptor complexes for IL-22, IL-26, IL-28, and IL-29.

Related Research Areas

• B Cell Development and Differentiation
• B Cell Markers
• Conventional/Classical Dendritic Cells
• Cytokines and Receptors in Allergy and Asthma
• Cytokines and Receptors in Angiogenesis
• Cytokines and Receptors in Tfh Cell Differentiation and Function
• gamma delta T Cells
• IL-10 Family
• Inflammatory Mediators
• Isolation, Culture, and Identification of Natural Killer Cells
• Lymphoma
• Macrophage Activation Markers
• Microglia Activation Markers
• Microglia Homeostasis
• Molecules Secreted by VSMC
• Monocyte Markers
• Multiple Sclerosis and Myelin Related Molecules
• Myeloid-derived Suppressor Cells (MDSC)
• Natural Killer T (NKT) Cells
• Neuroinflammatory Factors
• Plasmacytoid Dendritic Cells
• Regulatory T Cells (Tregs)
• Search Cytokine and Growth Factor Products
• T Cell Cytokine Signaling
• Th1 Cells
• Th2 Cells
• Th22 Cells
• Th9 Cells