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CyPPA

Catalog #: 2953
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2953/5
2953/25
CyPPA | CAS No. 73029-73-9 | Ca2+-Activated Potassium Channel Activators
1 Image
Description: KCa2.2 and KCa2.3 (SK) channel activator

Chemical Name: N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CyPPA is an activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels (EC50 values are 5.6 and 14 μM for KCa2.3 and KCa2.2 respectively). Displays no activity at KCa2.1 (SK1) and KCa3.1 (IK) channels.

Technical Data

M.Wt:
285.39
Formula:
C16H23N5
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
73029-73-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for CyPPA

The citations listed below are publications that use Tocris products. Selected citations for CyPPA include:

2 Citations: Showing 1 - 2

  1. Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines.
    Authors: Abdulkareem Et al.
    J Exp Clin Cancer Res  2016;173:177
  2. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
    Authors: Benton Et al.
    J Neurophysiol  2013;109:2528

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