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Cytarabine

Catalog #: 4520
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4520/50
Cytarabine | CAS No. 147-94-4 | DNA, RNA and Protein Synthesis Inhibitors
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Description: Nucleoside analog; inhibits DNA replication
Alternative Names: Cytosine b-D-arabinofuranoside

Chemical Name: 4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone

Purity: ≥98%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Cytarabine is a nucleoside analog of deoxycytidine; inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines). Displays no inhibitory effects on RNA synthesis. Causes S phase cell cycle arrest in ML-1 cell lines; cytotoxic in L5817Y leukemia cells. Antineoplastic and antileukemic agent.

Technical Data

M.Wt:
243.22
Formula:
C9H13N3O5
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
147-94-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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⚠ WARNING: This product can expose you to chemicals including Cytarabine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Cytarabine

The citations listed below are publications that use Tocris products. Selected citations for Cytarabine include:

6 Citations: Showing 1 - 6

  1. Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors.
    Authors: Karen Et al.
    Curr Protoc  2021;1:e141
  2. The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG.
    Authors: Uwe Et al.
    Cancer Discov  2021;11:500-519
  3. SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine.
    Authors: Oliver T Et al.
    Commun Biol  2020;3:324
  4. Knockdown of BNIP3L or SQSTM1 alters cellular response to mitochondria target drugs.
    Authors: Paul A Et al.
    Autophagy  2019;15:900-907
  5. Systematic analysis of protein turnover in primary cells.
    Authors: Mathieson Et al.
    Nat Commun  2018;9:689
  6. Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression.
    Authors: Bisikirska Et al.
    Cancer Res  2016;76:664

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