D-Aspartic acid
Chemical Name: D-Aminosuccinic acid
Biological Activity
D-Aspartic acid is an endogenous NMDA receptor agonist with similar activity to the L-isomer. Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland.L-isomer also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Free D-aspartate and D-serine in the mammalian brain and periphery.
Hashimoto et al.
Prog.Neurobiol., 1997;53:325 -
D-Aspartate modulates melatonin synthesis in rat pinealocytes.
Ishio et al.
Neurosci.Lett., 1998;249:143 -
Structure/activity relations of NMDA receptor ligands as studied by their inhibition of 3H-D-AP5 binding in rat brain membranes.
Olverman et al.
Neuroscience, 1988;26:17
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Citation for D-Aspartic acid
The citations listed below are publications that use Tocris products. Selected citations for D-Aspartic acid include:
1 Citation: Showing 1 - 1
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DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
Authors: Cai and Ford
Cell Rep 2018;25:3148
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