D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt

Name: D- myo -Inositol-1,3,4,5- tetrakis phosphate, octapotassium salt
Brand: Tocris Bioscience
SKU: 1420

Catalog #: 1420 Datasheet / COA / SDS

Discontinued Product

1420 has been discontinued.

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D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt | CAS No. 145843-69-2 | Inositol Phosphatase Inhibitors

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Description: Potent inhibitor of Ins(1,4,5)P3 5-phosphatase. Metabolite of Cat. No. 1482

Purity: ≥98%

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Biological Activity

D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt is a phosphorylation product of inositol 1,4,5-trisphosphate (Ins (1,4,5)P₃). Potent inhibitor of Ins (1,4,5)P₃ 5-phosphatase (IC₅₀ ~150 nM); facilitates Ca²⁺ influx by sensitizing Ins (1,4,5)P₃-mediated activation of I_CRAC. At higher concentrations, acts as an inhibitor of Ins (1,4,5)P₃ receptors.

Technical Data

M.Wt:

804.73

Formula:

C₆H₈O₁₈P₄.K₈

Solubility:

Soluble in water

Purity:

≥98%

Storage:

Desiccate at -20°C

CAS No:

145843-69-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Agonist-induced calcium signaling is impaired in fibroblasts overproducing inositol 1,3,4,5-tetrakisphosphate.
Balla et al.
J.Biol.Chem., 1991;266:24719
Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling.
Cullen et al.
Biochim.Biophys.Acta, 1998;1436:35
InsP₄ facilitates store-operated calcium influx by inhibition of InsP₃ 5-phosphatase.
Hermosura et al.
Nature, 2000;408:735

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