Home / Additional Apoptosis-related Compounds / (D)-PPA 1

(D)-PPA 1

Catalog #: 6515
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6515/1
(D)-PPA 1
1 Image
Description: PD-1/PD-L1 interaction inhibitor

Purity: ≥95%

Product Details
Citations (1)
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Biological Activity

(D)-PPA 1 is a PD-1/PD-L1 interaction inhibitor. Binds to PD-L1 (Kd = 0.51 μM). Inhibits interaction at 1 mg/mL in flow cytometry. Inhibits tumor growth and prolongs survival time of mice in vivo.

Technical Data

M.Wt:
1555.67
Formula:
C70H98N20O21
Sequence:
NYSKPTDRQYHF

(Modifications: Asn-1 = D-Asn, Tyr-2 = D-Tyr, Ser-3 = D-Ser, Lys-4 = D-Lys, Pro-5 = D-Pro, Thr-6 = D-Thr, Asp-7 = D-Asp, Arg-8 = D-Arg, Gln-9 = D-Gln, Tyr-10 = D-Tyr, His-11 = D-His, Phe-12 = D-Phe)

Solubility:
Soluble to 2 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1620813-53-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Blocking of the PD-1/PD-L1 interaction by a D-peptide antagonist for cancer immunotherapy.
    Chang et al.
    Angew Chem.Int.Ed.Engl., 2015;54:11760

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Citation for (D)-PPA 1

The citations listed below are publications that use Tocris products. Selected citations for (D)-PPA 1 include:

1 Citation: Showing 1 - 1

  1. Tumor-associated neutrophils activated by tumor-derived CCL20 (C-C motif chemokine ligand 20) promote T cell immunosuppression via programmed death-ligand 1 (PD-L1) in breast cancer.
    Authors: Qiang Et al.
    Bioengineered  2021;12:6996-7006

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