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D-Serine

Catalog #: 0226
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0226/1G
D-Serine | CAS No. 312-84-5 | Additional NMDA Receptor Compounds
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Description: Potentiator of NMDA recepors; acts at glycine site
Product Details
Citations (8)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

D-Serine is a glycine agonist at the NMDA receptor.

Technical Data

M.Wt:
105.09
Formula:
C3H7NO3
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
312-84-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Contribution of astroglial Cx43 hemichannels to the modulation of glutamatergic currents by D-serine in the mouse prefrontal cortex
    C Meunier, N Wang, C Yi, G Dallerac, P Ezan, A Koulakoff, L Leybaert, C Giaume
    J. Neurosci., 2017;0(0):.
  2. D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
    Mothet et al.
    Proc.Natl.Acad.Sci.USA, 2000;97:4926
  3. D-Serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors.
    Schell et al.
    J. Neurosci., 1997;17:1604
  4. Non-competitive NMDA antagonists.
    Lodge
    The NMDA Receptor (2nd edition). Eds. G.L.Collingr, 1989;:37

Product Datasheets

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Citations for D-Serine

The citations listed below are publications that use Tocris products. Selected citations for D-Serine include:

8 Citations: Showing 1 - 8

  1. Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation.
    Authors: Romanos Et al.
    Commun Biol  2019;2:127
  2. Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement.
    Authors: Adamsky Et al.
    Cell  2018;174:59
  3. Optical control of NMDA receptors with a diffusible photoswitch.
    Authors: Laprell Et al.
    Proc Natl Acad Sci U S A  2015;6:8076
  4. Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    J Neurosci  2015;112:8124
  5. Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after PilC-induced status epilepticus.
    Authors: Lee Et al.
    J Biol Chem  2012;7:e38789
  6. Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
    Authors: Potier Et al.
    Front Aging Neurosci  2010;2:1
  7. NMDA- and β-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice.
    Authors: Inoue Et al.
    PLoS One  2008;28:14486
  8. Subpallial origin of a population of projecting pioneer neurons during corticogenesis.
    Authors: Morante-Oria Et al.
    Proc Natl Acad Sci U S A  2003;100:12468

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