Dansyl-NECA
Chemical Name: 1-Deoxy-1-[6-[[6-[[[5-dimethylamino)-1-naphthalenyl]sulfonyl]amino]hexyl]amino]-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamide
Purity: ≥99%
Biological Activity
Dansyl-NECA is a high affinity and selective fluorescent adenosine A1 receptor agonist (Ki values are 27, 3600 and 4300 nM for A1, A3 and A2 receptors, respectively). Permits visualization of A1 receptors in the rat cerebellar cortex.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Fluorescent ligands for adenosine receptors.
Kozma et al.
Bioorg. Med. Chem. Lett., 2013;23:26 -
Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives.
Macchia et al.
Bioorg. Med. Chem. Lett., 1998;8:3223
Product Datasheets
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