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DCEBIO

Catalog #: 1422
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1422/10
1422/50
DCEBIO | CAS No. 60563-36-2 | CFTR Activators
1 Image
Description: Activates Cl- conductance and hKCa3.1 channels

Chemical Name: 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one

Purity: ≥99%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

DCEBIO is a stimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).

Technical Data

M.Wt:
231.08
Formula:
C9H8Cl2N2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
60563-36-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. DCEBIO stimulates Cl- secretion in the mouse jejunum.
    Hamilton and Kiessling et al.
    Am.J.Physiol.Cell Physiol., 2006;290:152
  2. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease.
    Singh et al.
    J.Pharmacol.Exp.Ther., 2001;296:600

Product Datasheets

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Citations for DCEBIO

The citations listed below are publications that use Tocris products. Selected citations for DCEBIO include:

5 Citations: Showing 1 - 5

  1. Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells.
    Authors: McCully Et al.
    J Immunol  2015;195:96
  2. Benzimidazolones enhance the function of epithelial Na+ transport.
    Authors: Laube Et al.
    Br J Pharmacol  2013;168:1329
  3. Loss of Ca-mediated ion transport during colitis correlates with reduced ion transport responses to a Ca-activated K channel opener.
    Authors: Hirota and McKay
    Br J Pharmacol  2009;156:1085
  4. Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR.
    Authors: MacVinish Et al.
    J Reprod Dev  2007;150:1055
  5. Intermediate-conductance Ca2+-activated K+ channel is expressed in C2C12 myoblasts and is downregulated during myogenesis.
    Authors: Fioretti Et al.
    Am J Physiol Cell Physiol  2005;289:C89

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