DDR1-IN-1 dihydrochloride
Chemical Name: N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride
Purity: ≥98%
Biological Activity
DDR1-IN-1 dihydrochloride is a selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50 values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of DDR1-IN-1 is reviewed on the chemical probes website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A new path to platelet production through matrix sensing
V Abbonante, CA Di Buduo, C Gruppi, C De Maria, E Spedden, A De Acutis, C Staii, M Raspanti, G Vozzi, D Kaplan, F Moccia, K Ravid, A Balduini
Haematologica, 2017;0(0):. -
Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.
Kim et al.
ACS.Chem.Biol., 2013;8:2145 -
Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors.
Canning et al.
J.Mol.Biol., 2014;426:2457
Product Datasheets
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Citations for DDR1-IN-1 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for DDR1-IN-1 dihydrochloride include:
6 Citations: Showing 1 - 6
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Breast tissue regeneration is driven by cell-matrix interactions coordinating multi-lineage stem cell differentiation through DDR1.
Authors: Piyush B Et al.
Nat Commun 2021;12:7116
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Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease.
Authors: Adria Et al.
Mol Metab 2020;39:101006
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Silencing of sinusoidal DDR1 reduces murine liver metastasis by colon carcinoma.
Authors: Romayor Et al.
Sci Rep 2020;10:18398
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Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity.
Authors: Vehlow Et al.
Cell Rep 2019;26:3672
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Collagen Type 1 accelerates healing of ruptured fetal membranes.
Authors: Mogami
Sci Rep 2018;8(1):696
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Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses.
Authors: Malaguarnera Et al.
BMC Complement Altern Med 2015;6:16084
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