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Desipramine hydrochloride

Catalog #: 3067
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3067/50
Desipramine hydrochloride | CAS No. 58-28-6 | Adrenergic Transporter Inhibitors
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Description: Selective inhibitor of noradrenalin transporters

Chemical Name: 10-11-Dihydro-N-methyl-5H-dibenz(Z)[b,f]azepine-5-propanamine hydrochloride

Purity: ≥99%

Product Details
Citations (8)
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Biological Activity

Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).

Technical Data

M.Wt:
302.84
Formula:
C18H22N2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
58-28-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics
    Sarah W Black
    Biol. Psychiatry, 2016;0(0):.
  2. Plasma membrane monoamine transporters: structure, regulation and function.
    Torres et al.
    Nat.Rev.Neurosci., 2003;4:13
  3. NE transporter regulation mediates the long-term behavioral effects of the antidepressant desipr.
    Zhao et al.
    Neuropsychopharmacol., 2008;33:3190

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Citations for Desipramine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Desipramine hydrochloride include:

8 Citations: Showing 1 - 8

  1. A mesocortical DA circuit enables the cultural transmission of vocal behaviour.
    Authors: Tanaka Et al.
    Nature  2018;563:117
  2. Combinatorial Expression of Grp and Neurod6 Defines DA Neuron Populations with Distinct Projection Patterns and Disease Vulnerability.
    Authors: Kramer Et al.
    Eneuro  2018;5
  3. (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
    Authors: Chou Et al.
    Neuropharmacology  2018;139:1
  4. CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis.
    Authors: LaRocca Et al.
    Neuropsychopharmacology  2015;6:e1773
  5. Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
    Authors: Czysz Et al.
    Proc Natl Acad Sci U S A  2015;40:766
  6. Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.
    Authors: Bucher Et al.
    J Cereb Blood Flow Metab  2014;34:1128
  7. Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons.
    Authors: Yuen Et al.
    J Biol Chem  2014;289:25177
  8. Changes in c-Fos Expression in the Forced Swimming Test: Common and Distinct Modulation in Rat Brain by desipr. and cital.
    Authors: Choi Et al.
    Korean J Physiol Pharmacol  2013;17:321

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