Diazepam

Name: Diazepam
Brand: Tocris Bioscience
SKU: 2805
Price: 133 USD

Catalog #: 2805
8 Citations Datasheet / COA / SDS

Discontinued Product

2805 has been discontinued.

View all GABA-A Receptor Benzodiazepines products.

Diazepam | CAS No. 439-14-5 | GABA-A Receptor Benzodiazepines

1 Image

Description: Acts at the benzodiazepine modulatory site

Alternative Names: Ro 5-2807

Chemical Name: 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2(1H)-one

Purity: ≥98%

View All Products for GABA-A Receptor Benzodiazepines

Product Details

Citations (8)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Diazepam is a ligand at the GABA_A receptor benzodiazepine modulatory site. Anxiolytic, anticonvulsant and sedative/hypnotic agent.

Technical Data

M.Wt:

284.74

Formula:

C₁₆H₁₃ClN₂O

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

439-14-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Pharmacology of benzodiazepine receptors: an update.
Sieghart et al.
J.Psychiat.Neurosci., 1994;19:24

Product Datasheets

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Diazepam

The citations listed below are publications that use Tocris products. Selected citations for Diazepam include:

8 Citations: Showing 1 - 8

Structure of a human synaptic GABAA receptor.
Authors: Zhu
Nature 2018;559(7712):67
Local GABA_A receptor mediated suppression of DA release within the nucleus accumbens.
Authors: Brodnik Et al.
ACS Chem Neurosci 2018;17:1978
Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
Authors: Czysz Et al.
PLoS One 2015;40:766
In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383.
Authors: Ufuk Et al.
Pharm Res 2015;32:3937
Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT?A and 5-HT? Antagonists in Animal Models.
Authors: Pytka Et al.
PLoS One 2015;10:e0142499
Membrane potential measurements of isolated neurons using a voltage-sensitive dye.
Authors: Fairless Et al.
PLoS One 2013;8:e58260
A translational rodent assay of affective biases in depression and antidepressant therapy.
Authors: Stuart Et al.
Neuropsychopharmacology 2013;38:1625
A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure.
Authors: Huang Et al.
J Neurosci 2010;30:16636

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