Diazoxide

Catalog #: 0964
4 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0964/100

Diazoxide | CAS No. 364-98-7 | AMPA Receptor Compounds

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Description: Inhibits AMPA desensitization

Chemical Name: 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

Purity: ≥98%

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Product Details

Citations (4)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Diazoxide is an antihypertensive, activates ATP-dependent K⁺ channels (K_ir6). Induces activation of PKCε, an intermediate in the opening of mitoK_ATP channels, results in cardioprotection against hypoxia-induced death. Blocks desensitization of AMPA receptors.

Technical Data

M.Wt:

230.67

Formula:

C₈H₇ClN₂O₂S

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

364-98-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Dox acts more as a PKC-ε activator, and indirectly activates the mitochondiral K_ATP channel conferring cardioprotection against hypoxic injury.
Kim et al.
Br.J.Pharmacol., 2006;149:1059
Dox blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons.
Yamada and Rothman
J.Physiol., 1992;458:409
Opposite effects of tolbut. and Dox on the ATP-dependent K⁺ channel in mouse pancreatic β-cells.
Trube et al.
Pflugers Arch., 1986;407:493

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⚠ WARNING: This product can expose you to chemicals including Diazoxide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Diazoxide

The citations listed below are publications that use Tocris products. Selected citations for Diazoxide include:

4 Citations: Showing 1 - 4

Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel.
Authors: Sun Et al.
Sci Rep 2014;4:4934
Chronic neonatal Dox therapy is not associated with adverse effects
Authors: Cox Et al.
J Neurosci 2014;14:49
Shift in Kiss1 cell activity requires estrogen receptor α.
Authors: Frazão Et al.
J Neurosci 2013;33:2807
Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition.
Authors: Niu Et al.
Neuroscience 2011;180:344

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