Diclofenac sodium salt
Chemical Name: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Purity: ≥99%
Biological Activity
Diclofenac sodium salt is a nonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC50 values are 0.075 μM for COX-1 and 0.038 μM for COX-2 in human whole blood assay).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.
Warner et al.
Proc.Natl.Acad.Sci.USA, 1999;96:7563 -
Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity.
Bort et al.
J.Pharmacol.Exp.Ther., 1998;288:65 -
Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.
Laneuville et al.
J.Pharmacol.Exp.Ther., 1994;271:927
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Citation for Diclofenac sodium salt
The citations listed below are publications that use Tocris products. Selected citations for Diclofenac sodium salt include:
1 Citation: Showing 1 - 1
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Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells.
Authors: Timothy S Et al.
J Immunol 2021;207:1275-1287
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