Dihydrexidine hydrochloride
Chemical Name: (±)-trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine hydrochloride
Purity: ≥98%
Biological Activity
Dihydrexidine hydrochloride is an a potent, full efficacy dopamine D1 agonist which shows no agonist activity at peripheral D2 receptors or adrenoceptors at doses which cause maximal stimulation of D1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors
Eva Hedlund
Sci Rep, 2016;6(0):26448. -
Trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective DA D1 full agonist.
Brewster et al.
J.Med.Chem., 1990;33:1756 -
Dihydrexidine: a new potent peripheral DA D1 receptor agonist.
Kholi et al.
Eur.J.Pharmacol., 1993;235:31 -
Dihydrexidine, a novel selective high potency, full DA D-1 receptor agonist.
Lovenberg et al.
Eur.J.Pharmacol., 1989;166:111 -
Dihydrexidine, a full DA D1 agonist, reduces MPTP-induced parkinsonism in monkeys.
Taylor et al.
Eur.J.Pharmacol., 1991;199:389
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Citations for Dihydrexidine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Dihydrexidine hydrochloride include:
4 Citations: Showing 1 - 4
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Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions.
Authors: Parker and Kooi
J Neurosci 2014;453:42525
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CODA-RET reveals functional selectivity as a result of GPCR heteromerization.
Authors: Urizar Et al.
Anal Biochem 2011;7:624
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DArgic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons.
Authors: Smith Et al.
Neuron 2005;45:765
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Mechanisms of DA activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex.
Authors: Gorelova Et al.
J Neurophysiol 2002;88:3150
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I used this as our positive control when testing dose responses following treatment with our Tango D1-bla U20S cells to measure dopamine receptor 1 activity following treatment with Dihydrexidine.
