Diltiazem hydrochloride

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Effects of dilt. on bioenergetics, K⁺ gradients, and free cytosolic Ca²⁺ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization.
   Dagani et al.
   J.Neurochem., 1989;53:1379
3. Block of P-type Ca²⁺ channels in freshly dissociated rat cerebellar Purkinje neurons by dilt. and vera.
   Ishibashi et al.
   Brain Res., 1995;695:88
4. Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by dilt.
   Gandia et al.
   Br.J.Pharmacol., 1996;118:1301
5. Molecular mechanisms of dilt. interaction with L-type Ca²⁺ channels.
   Kraus et al.
   J.Biol.Chem., 1998;273:27205
6. Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses
   J Mitlöhner, R Kaushik, H Niekisch, A Blondiaux, CE Gee, MFK Happel, E Gundelfing, A Dityatev, R Frischknec, C Seidenbech
   Cells, 2020;9(2):.

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