DIM-C-pPhOCH3
Chemical Name: 1,1-Bis(3'-indolyl)-1-(p-methoxyphenyl)methane
Purity: ≥98%
Biological Activity
DIM-C-pPhOCH3 is a Nur77 agonist. Induces apoptosis in cancer cell lines in vitro. Enhances long-term potentiation in hippocampal slices and long-term contextual fear memory in an in vivo mouse model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological activators of the NR4A nuclear receptors enhance LTP in a CREB/CBP-dependent manner.
Bridi et al.
Neuropsychopharmacology, 2017;42:1243 -
Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
Chintharlapalli et al.
J.Biol.Chem., 2005;280:24903
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