DIM-C-pPhOH
Chemical Name: 1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
Purity: ≥98%
Biological Activity
DIM-C-pPhOH is a Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines. Mimics effects of Nur77 RNAi silencing.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Activation of Nur77 by selected 1,1-Bis(3-indolyl)-1- (p-substituted phenyl)methanes induces apoptosis through nuclear pathways.
Chintharlapalli et al.
J.Biol.Chem, 2005;280:24903 -
NR4A1 antagonists inhibit 1-Integrin-dependent breast cancer cell migration.
Hedrick et al.
Mol.Cell.Biol, 2016;36:1383 -
The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells.
Lee et al.
Mol.Cancer Res., 2014;12:527
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