DIPPA hydrochloride
Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride
Purity: ≥99%
Biological Activity
DIPPA hydrochloride is an an irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice.
Chang et al.
J.Med.Chem., 1994;37:1547 -
κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists.
Chang et al.
J.Med.Chem., 1994;37:4490
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Citations for DIPPA hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for DIPPA hydrochloride include:
2 Citations: Showing 1 - 2
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Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
Authors: Jones Et al.
Biochem Pharmacol 2010;80:1478
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Comparison of the kappa-opioid receptor antagonist DIPPA in tests of anxiety-like behavior between Wistar Kyoto and Sprague Dawley rats.
Authors: Carr and Lucki
Psychopharmacology (Berl) 2010;210:295
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