Diprotin A
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Description: Dipeptidyl peptidase IV (DPP-IV) inhibitor
Alternative Names: Ile-Pro-Ile
Chemical Name: L-Isoleucyl-L-prolyl-L-isoleucine
Purity: ≥98%
Biological Activity
Diprotin A is a dipeptidyl peptidase IV (DPP-IV) inhibitor. Inhibits hydrolysis of incretins, regulating blood glucose levels. Induces Src and vascular endothelium-cadherin phosphorylation, increasing vascular permeability in the retina. Also increases number of viable phenotypic long term repopulating hematopoietic stem cells when harvesting mouse bone marrow in aerobic conditions.Technical Data
M.Wt:
341.45
Formula:
C17H31N3O4
Sequence:
IPI
Solubility:
Soluble to 100 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
90614-48-5
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else?
Juillerat-Jeanneret et al.
J.Med.Chem., 2014;57:2197 -
Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation.
Lim et al.
Korean J.Intern.Med., 2015;30:759 -
Dipeptidyl peptidase-4 inhibitor increases vascular leakage in retina through VE-cadherin phosphorylation.
Lee et al.
Sci.Rep., 2016;6:29393
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