DL-AP3
Chemical Name: DL-2-Amino-3-phosphonopropionic acid
Biological Activity
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
Evans et al.
Br.J.Pharmacol., 1982;75:65 -
The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase.
Hawkinson et al.
Eur.J.Pharmacol., 1996;307:219 -
L-2-Amino-3-phosphonopropionic acid completely antagonizes metabotropic glutamate receptors 1α and 5 in Xenopus oocytes.
Saugstad et al.
Eur.J.Pharmacol., 1995;289:395
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Citation for DL-AP3
The citations listed below are publications that use Tocris products. Selected citations for DL-AP3 include:
1 Citation: Showing 1 - 1
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PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors.
Authors: Vance Et al.
J Neurosci 2015;35:776
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