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DMH2

Catalog #: 5580
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5580/10
5580/50
DMH2 | CAS No. 1206711-14-9 | BMP and Other Activin Receptor Inhibitors
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Description: Type I BMP receptor inhibitor

Chemical Name: 4-[6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

DMH2 is a type I BMP receptor inhibitor (Ki values are <1, 5.4 and 43 nM for ALK6, ALK3 and ALK2, respectively). Exhibits >30-fold selectivity over ALK4, ALK5, BMPR2, AMPK and VEGFR2. Also binds to TGFBR2 (Ki = 85 nM). Decreases growth and induces cell death of H1299 non-small cell lung carcinoma cells in vitro. Enhances liver regeneration in vivo.

Technical Data

M.Wt:
451.52
Formula:
C27H25N5O2
Solubility:
Soluble to 50 mM in 2eq.HCl and to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1206711-14-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Specific AVNreceptor-like kinase 3 inhibitors enhance liver regeneration.
    Tsugawa et al.
    J.Pharmacol.Exp.Ther., 2014;351:549

Product Datasheets

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Citations for DMH2

The citations listed below are publications that use Tocris products. Selected citations for DMH2 include:

2 Citations: Showing 1 - 2

  1. Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.
    Authors: Gerard Et al.
    JCI Insight  2021;6
  2. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.
    Authors: Stuart Et al.
    Cell Stem Cell  2019;25:388

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