DMNPE-4 AM-caged-calcium
Chemical Name: Bis(acetoxymethyl) 3,12-bis(2-(acetoxymethoxy)-2-oxoethyl)-5-(4,5-dimethoxy-2-nitrophenyl)-6,9-dioxa-3,12-diazatetradecane-1,14-dioate
Purity: ≥95%
Biological Activity
DMNPE-4 AM-caged-calcium is a calcium cage. In the presence of calcium, the compound will chelate and cage calcium (Kd values are 48 and 19 nM at pH 7.2 and 7.4, respectively; Kd after uncaging = 2 mM). DMNPE-4 AM-caged-calcium is selective for Ca2+ over Mg2+ (Kd = 10 mM). Rapid and efficient calcium release occurs upon photolysis at 350 nm. It can also be used for two-photon uncaging. Extinction coefficient of 5120 M-1 cm-1, quantum yield 0.09. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Spontaneous activity of cochlear hair cells triggered by fluid secretion mechanism in adjacent support cells
Wang et al.
Cell, 2015;163:1348 -
Brain metabolism dictates the polarity of astrocyte control over arterioles.
Gordon et al.
Nature, 2008;456:745 -
Tuning caged calcium: photolabile analogues of EGTA with improved optical and chelation properties.
Ellis-Davies et al.
Cell Calcium, 2006;39:75
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