Docosahexaenoic acid

Catalog #: 3687
3 Citations Datasheet / COA / SDS

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3687/100

Docosahexaenoic acid | CAS No. 6217-54-5 | Retinoid X Receptor Agonists

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Description: RXR agonist

Alternative Names: DHA

Chemical Name: (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-Docosahexaenoic acid

Purity: ≥98%

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Product Details

Citations (3)

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Biological Activity

Docosahexaenoic acid is a endogenous omega-3 fatty acid. Acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Activates all three RXR isoforms. Also shown to inhibit Aβ1-42 fibrillation and toxicity in vitro.

Technical Data

M.Wt:

328.49

Formula:

C₂₂H₃₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

6217-54-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain.
Mata de Urqunia et al.
Science, 2000;290:2140
Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ: RXR heterodimers: comparison with other polyunsaturated fatty acids.
Zapata-Gonzalez et al.
J.Leukoc.Biol., 2008;84:1172
Mechanism of docosahexaenoic acid-induced inhibition of in vitro Aβ_1-42 fibrillation and Aβ_1-42-induced toxicity in SH-S5Y5 cells.
Hossain et al.
J.Neurochem., 2009;111:568

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Citations for Docosahexaenoic acid

The citations listed below are publications that use Tocris products. Selected citations for Docosahexaenoic acid include:

3 Citations: Showing 1 - 3

Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer.
Authors: Pal Et al.
J Ovarian Res 2019;12:49
Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells.
Authors: Wnuk Et al.
Mol Neurobiol 2018;55:5059
Phagocytosis-dependent ketogenesis in retinal pigment epithelium.
Authors: Reyes-Reveles Et al.
J Biol Chem 2017;292:8038

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