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Dolasetron mesylate

Catalog #: 5629 Datasheet / COA / SDS

Discontinued Product

5629 has been discontinued.
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Dolasetron mesylate | CAS No. 115956-13-3 | 5-HT3 Receptor Antagonists
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Description: Potent and selective 5-HT3 antagonist

Chemical Name: 3-Oxooctahydro-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate methanesulfonate

Purity: ≥99%

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Biological Activity

Potent and selective 5-HT3 receptor antagonist (pIC50 = 7.55). Exhibits 200-fold selectivity for 5-HT3 over 5-HT1A, 5-HT1B and 5-HT2 receptors, and a range of other GPCRs. Blocks the 5-HT-elicited von Bezold-Jarisch reflex in rats and suppresses cisplatin-induced vomiting in ferrets.

Technical Data

M.Wt:
420.48
Formula:
C19H20N2O3.CH3SO3H
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
115956-13-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological properties of dolasetron, a potent and selective antagonist at 5-HT3 receptors.
    Miller
    Drug Dev. Res., 1993;28:87

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