Donitriptan hydrochloride
Chemical Name: 1-[[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]acetyl]-4-(4-cyanophenyl)-piperazine hydrochloride
Purity: ≥98%
Biological Activity
Brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively). Inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Displays antimigraine activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief.
Letienne et al.
J.Pharmacol.Exp.Ther., 2003;305:749 -
Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action?
Letienne et al.
J.Pharmacol.Exp.Ther., 2005;315:849 -
Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilation via 5-HT1B rather than 5-HT1D receptors.
Munoz-Islas et al.
Br.J.Pharmacol., 2006;149:82
Product Datasheets
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