Home / NMDA Receptor Antagonists / DQP 1105

DQP 1105

Catalog #: 4491
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4491/10
4491/50
DQP 1105 | CAS No. 380560-89-4 | NMDA Receptor Antagonists
1 Image
Description: GluN2C/GluN2D-selective NMDA antagonist

Chemical Name: 5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-γ-oxo-1H-pyrazole-1-butanoic acid

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

DQP 1105 is a noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 μM, respectively). Reduces frequency of channel opening.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
558.42
Formula:
C29H24BrN3O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
380560-89-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for DQP 1105

The citations listed below are publications that use Tocris products. Selected citations for DQP 1105 include:

2 Citations: Showing 1 - 2

  1. Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling.
    Authors: Brancaccio Et al.
    Neuron  2017;93:1420
  2. Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.
    Authors: Lozovaya Et al.
    Nat Commun  2014;5:4563

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for DQP 1105

There are currently no reviews for this product. Be the first to review DQP 1105 and earn rewards!

Have you used DQP 1105?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.