Drosophila Decapentaplegic/DPP Antibody Summary
Asp457-Arg588 (Gln473His, Pro474Ala)
Accession # NP_722813.1
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Decapentaplegic/DPP
Decapentaplegic (Dpp) is one of at least five TGF-beta superfamily ligands identified in the Drosophila genome. Dpp, a functional orthologue of mammalian BMP-2 and BMP-4, is a morphogen and plays an essential role in Drosophila development. Dpp regulates embryonic dorsal-ventral polarity and is required for gut morphogenesis and outgrowth and patterning of imaginal disks. Similar to other TGF-beta family ligands, Dpp is synthesized as a large proprotein which is proteolytically processed at the dibasic cleavage site to release the carboxy-terminal domain. Biologically active Dpp is a disulfide-linked homodimer of the carboxy-terminal 132 amino acid residues that contains the characteristic conserved cysteine residues involved in the formation of the cysteine knot and the interchain disulfide bond. Cellular responses to Dpp have been shown to be mediated by the ligand-induced formation of heteromeric complexes of the Drosophila type I, Thick Veins (Tkv), and type II, Punt, serine/threonine kinases. The activated receptor complex induces the phosphorylation of the prototypical Smad, Mad, and subsequent translocation of the Mad‑Medea complex to the nucleus where they regulate the transcription of target genes. Secreted extracellular Dpp antagonists, including the short-gastrulation (Sog) and twisted gastrulation (TSG), which bind Dpp and regulate its availability, have been identified.
Product Datasheets
Citations for Drosophila Decapentaplegic/DPP Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Enhanced germline stem cell longevity in Drosophila diapause
Authors: S Easwaran, M Van Ligten, M Kui, DJ Montell
Nature Communications, 2022-02-07;13(1):711.
Species: Drosophila melanogaster
Sample Types: Ovaries
Applications: IHC -
Diet regulates membrane extension and survival of niche escort cells for germline homeostasis via insulin signaling
Authors: YH Su, E Rastegri, SH Kao, CM Lai, KY Lin, HY Liao, MH Wang, HJ Hsu
Development, 2018-04-05;0(0):.
Species: Drosophila
Sample Types: Tissue Homogenates
Applications: Western Blot -
Host and pathogen glycosaminoglycan-binding proteins modulate antimicrobial peptide responses in Drosophila melanogaster.
Authors: Wang Z, Flax LA, Kemp MM, Linhardt RJ, Baron MJ
Infect. Immun., 2010-11-15;79(2):606-16.
Species: Drosophila
Sample Types:
Applications: ELISA Development -
Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling.
Authors: Martinez AM, Schuettengruber B, Sakr S, Janic A, Gonzalez C, Cavalli G
Nat. Genet., 2009-09-13;41(10):1076-82.
Species: Drosophila
Sample Types: Whole Tissue
Applications: IHC
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