Home / TAG Degradation Platforms / dTAG-Biotin

dTAG-Biotin

Catalog #: 7883 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7883/1
dTAG-Biotin | TAG Degradation Platforms
1 Image
Description: Affinity probe for mutant FKBP12F36V proteins

Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-((2,16-dioxo-20-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-6,9,12-trioxa-3,15-diazaicosyl)oxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

dTAG-Biotin is an affinity probe for mutant FKBP12F36V proteins. Comprises the ligand ortho-AP1867, selective for F36V single-point mutated FKBP12, joined by a PEG3 linker to biotin. It can be used for chemical biology studies such as proteomics, enrichment studies, dimerization experiments, and assay validation.

Technical Data

M.Wt:
1094.33
Formula:
C56H79N5O15S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The dTAG system for immediate and target-specific protein degradation.
    Nabet et al.
    Nat.Chem.Biol., 2018;14:431

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for dTAG-Biotin

There are currently no reviews for this product. Be the first to review dTAG-Biotin and earn rewards!

Have you used dTAG-Biotin?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.