Dynamin inhibitory peptide, myristoylated (control)
Biological Activity
Dynamin inhibitory peptide, myristoylated (control) is a control peptide version of dynamin inhibitory peptide, myristoylated, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. In contrast to dynamin inhibitory peptide, has no significant effect on GABAA receptor-mediated miniature IPSPs.Active Analog also available.
Technical Data
(Modifications: Gln-1 = Myr-Gln, Arg-10 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.
Grabs et al.
J.Biol.Chem., 1997;272:13419 -
Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons.
Kittler et al.
J.Neurosci., 2000;20:7972 -
Glycine binding primes NMDA receptor internalization.
Nong et al.
Nature, 2003;422:302
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Citations for Dynamin inhibitory peptide, myristoylated (control)
The citations listed below are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide, myristoylated (control) include:
3 Citations: Showing 1 - 3
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The Small GTPase Rac1 Contributes to Extinction of Aversive Memories of Drug Withdrawal by Facilitating GABAA Receptor Endocytosis in the vmPFC.
Authors: Wang Et al.
J Neurosci 2017;37:7096
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Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
J Neuroinflammation 2015;10:e0131430
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Pin1 and PKMzeta sequentially control dendritic protein synthesis.
Authors: Westmark Et al.
Sci Signal 2010;3:ra18
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