Dynamin inhibitory peptide
Purity: ≥95%
Biological Activity
Dynamin inhibitory peptide is a peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors.Cell-permeable version also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.
Grabs et al.
J.Biol.Chem., 1997;272:13419 -
Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons.
Kittler et al.
J.Neurosci., 2000;20:7972 -
Glycine binding primes NMDA receptor internalization.
Nong et al.
Nature, 2003;422:302
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for Dynamin inhibitory peptide
The citations listed below are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide include:
13 Citations: Showing 1 - 10
-
Clathrin-independent trafficking of AMPA receptors.
Authors: Glebov Et al.
J Biol Chem 2015;35:4830
-
NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.
Authors: Pleil Et al.
Nat Neurosci 2015;18:545
-
Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
Authors: Falgairolle and O'Donovan
J Neurosci 2015;10:e0131430
-
Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles.
Authors: Chiang Et al.
Nat Commun 2014;5:3356
-
Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons.
Authors: Yuen Et al.
J Biol Chem 2014;289:25177
-
Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons.
Authors: Chamma Et al.
J Neurosci 2013;33:15488
-
Inflammation-induced shift in spinal GABA(A) signaling is associated with a tyrosine kinase-dependent increase in GABA(A) current density in nociceptive afferents.
Authors: Zhu Et al.
J Neurophysiol 2012;108:2581
-
Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons.
Authors: Cuitino Et al.
PLoS One 2010;30:8411
-
DA D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
Authors: Graziane Et al.
J Neurosci 2009;284:8329
-
Surface-expressed viral proteins in feline infectious peritonitis virus-infected monocytes are internalized through a clathrin- and caveolae-independent pathway.
Authors: Dewerchin Et al.
J Gen Virol 2008;89:2731
-
In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression.
Authors: Grueter Et al.
J Neurosci 2008;28:9261
-
Activity-dependent synaptic plasticity in retinal ganglion cells.
Authors: Xia Et al.
J Neurosci 2007;27:12221
-
Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
Authors: Jiang Et al.
J Neurosci 2006;26:4318
FAQs
No product specific FAQs exist for this product, however you may
View all Peptide FAQsReviews for Dynamin inhibitory peptide
There are currently no reviews for this product. Be the first to review Dynamin inhibitory peptide and earn rewards!
Have you used Dynamin inhibitory peptide?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
