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Dynapyrazole A

Catalog #: 6896 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6896/5
6896/25
Dynapyrazole A | CAS No. 2226517-75-3 | Hedgehog Signaling Inhibitors
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Description: Hedgehog signaling inhibitor; dynein inhibitor

Chemical Name: 2-[1-(4-Chlorophenyl)cyclopropyl]-4,5-dihydro-7-iodo-5-oxopyrazolo[1,5-a]quinazoline-3-carbonitrile

Purity: ≥98%

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Biological Activity

Dynapyrazole A is a dynein inhibitor. Inhibits dynein 1 and dynein 2-dependent microtubule gliding (IC50 values are 2.3 and 2.6 μM, respectively). Inhibits hedgehog signaling in vitro (IC50 = 1.9 μM). Displays reversible inhibition of retrograde and anterograde intraflagellar transport in Chlamydomonas; displays stronger inhibition of retrograde transport.

Technical Data

M.Wt:
486.7
Formula:
C20H12ClIN4O
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2226517-75-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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