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eCF 309

Catalog #: 5955 Datasheet / COA / SDS

Discontinued Product

5955 has been discontinued.
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eCF 309 | CAS No. 2001571-40-8 | mTOR Inhibitors
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Description: Potent mTOR inhibitor

Chemical Name: 3-(2-Amino-5-benzoxazolyl)-1-(2,2-diethoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Purity: ≥98%

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Biological Activity

eCF 309 is a potent mTOR inhibitor (IC50 = 15 nM). Exhibits >60-fold selectivity for mTOR over PI 3-kinases and is inactive against a panel of other kinases. Inhibits growth of ER-positive MCF7 breast cancer cells in vitro (EC50 = 8.5 nM). Cell permeable.
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of eCF 309 is reviewed on the Chemical Probes website.

Technical Data

M.Wt:
383.41
Formula:
C18H21N7O3
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2001571-40-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. eCF309: a potent, selective and cell-permeable mTOR inhibitor.
    Fraser et al.
    Med.Chem.Commun., 2016;4:471

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