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EN 219

Catalog #: 7476 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7476/5
7476/25
EN 219 | CAS No. 380351-29-1 | RNF114
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Description: Covalent RNF114 ligand

Chemical Name: 1-[3,5-bis(4-Bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-2-chloroethanone

Purity: ≥98%

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Biological Activity

EN 219 is a covalent RNF114 inhibitor (IC50 = 470 nM). In vitro EN 219 mimics the mechanism of action of Nimbolide (Cat. No. 7289) by binding to RNF114 and inhibiting ubiquitination of its endogenous substrate, the tumor suppressor p21.

Technical Data

M.Wt:
456.56
Formula:
C17H13Br2ClN2O
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
380351-29-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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