Endomorphin-2
Purity: ≥95%
Biological Activity
Endomorphin-2 is a endogenous peptide with extremely high affinity and selectivity for μ-opioid receptors (with Ki values of 0.69, 9233 and 5240 nM for μ, δ and κ respectively).Technical Data
(Modifications: Phe-3 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat.
Chapman et al.
Br.J.Pharmacol., 1997;122:1537 -
Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain.
Goldberg et al.
J.Pharmacol.Exp.Ther., 1998;286:1007 -
Differential effects of endomorphin-1, endomorphin-2, and tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes.
Harrison et al.
Peptides, 1998;19:749 -
A potent and selective endogenous agonist for the μ-opiate receptor.
Zadina et al.
Nature, 1997;386:499
Product Datasheets
Citation for Endomorphin-2
The citations listed below are publications that use Tocris products. Selected citations for Endomorphin-2 include:
1 Citation: Showing 1 - 1
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RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance.
Authors: Garzón Et al.
Neuropsychopharmacology 2004;29:1091
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