Endothelin 3 (human, rat)
Purity: ≥95%
Biological Activity
Endothelin 3 (human, rat) is an endogenous neuropeptide and potent vasoconstrictor. Displays selectivity for the putative ETC endothelin receptor.Technical Data
(Modifications: Disulfide bridges: 1-15, 3-11)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
Inoue et al.
Proc.Natl.Acad.Sci.U.S.A., 1989;86:2863 -
Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes.
Servitja et al.
Br.J.Pharmacol., 1998;124:1728 -
Molecular biology and biochemistry of the endothelins.
Yanagisawa and Masaski
TiPS, 1989;10:374
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Citation for Endothelin 3 (human, rat)
The citations listed below are publications that use Tocris products. Selected citations for Endothelin 3 (human, rat) include:
1 Citation: Showing 1 - 1
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Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon.
Authors: Khan Et al.
Br J Pharmacol 2006;147:607
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Used at 100nM for deriving human melanocytes from iPSC cultures.
