Endoxifen
Chemical Name: (E/Z)-4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol
Purity: ≥98%
Biological Activity
Endoxifen is an estrogen receptor α (ERα) ligand; potent antiestrogen. Metabolite of tamoxifen (Cat. No. 0999). Primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells.
Lim et al.
J.Pharmacol.Exp.Ther., 2006;318:503 -
Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen.
Wu et al.
Breast Cancer Res., 2011;13:R27 -
The tamox. metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor a for degradation in breast cancer cells.
Wu et al.
Cancer Res., 2009;69:1722
Product Datasheets
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Citation for Endoxifen
The citations listed below are publications that use Tocris products. Selected citations for Endoxifen include:
1 Citation: Showing 1 - 1
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Divergent Effects of Daidzein and its Metabolites on Estrogen-Induced Survival of Breast Cancer Cells.
Authors: Maria Et al.
Cancers (Basel) 2020;12
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