Enterostatin

Biological Activity

N' terminal peptide fragment of procolipase that binds to the β-subunit of F1-ATPase. Activates the ERK and cAMP signaling pathways, and downregulates expression of Krüppel-like factor 4 (KLF4) and agouti-related peptide (AgRP) in vitro. Inhibits insulin secretion from pancreatic β-cells by downregulating expression of dynamin2 and altering protein trafficking. Reduces dietary fat intake via activation of CCK₁, induces satiety, enhances memory-consolidation and exhibits hypocholesterolemic activity in vivo. Orally active.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Enterostatin alters protein trafficking to inhibit Ins secretion in Beta-TC6 cells.
   Park et al.
   Peptides, 2009;30:1866

Product Datasheets