Home / Mineralocorticoid Receptor Antagonists / Eplerenone

Eplerenone

Catalog #: 2397
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2397/10
2397/50
Eplerenone | CAS No. 107724-20-9 | Mineralocorticoid Receptor Antagonists
1 Image
Description: Selective mineralocorticoid receptor antagonist
Alternative Names: Inspra,Epoxymexrenone

Chemical Name: (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Eplerenone is a selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.

Technical Data

M.Wt:
414.5
Formula:
C24H30O6
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
107724-20-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Genes implicated in insulin resistance are down-regulated in primary aldosteronism patients.
    Williams TA, Monticone S, Urbanet R
    Mol. Cell. Endocrinol., 2012;355(1):162-8.
  2. Topical Mineralocorticoid Receptor Blockade Limits Glucocorticoid-Induced Epidermal Atrophy in Human Skin.
    Maubec E, Laouenan C, Deschamps L, Nguyen V, Scheer-Senyarich I, Wackenheim-Jacobs A, Steff M, Duhamel S, Tubiana S, Brahimi N, Leclerc-Mercier S, Crickx B, Perret C, Aractingi S, Escoubet B, Duval X, Arnaud P, Jaisser F, Mentre F, Farman N
    J Invest Dermatol, 2015;135(7):1781-9.
  3. Re-Epithelialization of Pathological Cutaneous Wounds Is Improved by Local Mineralocorticoid Receptor Antagonism
    VT Nguyen, N Farman, E Maubec, D Nassar, D Desposito, L Waeckel, S Aractingi, F Jaisser
    J. Invest. Dermatol., 2016;136(10):2080-9.
  4. Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro.
    De Gasparo et al.
    J.Pharmacol.Exp.Ther., 1987;240:650
  5. Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.
    McMahon and Cunningham
    Curr.Opin.Pharmacol., 2001;1:190

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Eplerenone

The citations listed below are publications that use Tocris products. Selected citations for Eplerenone include:

2 Citations: Showing 1 - 2

  1. Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and DEX Analgesia in an Animal Model of Low Back Pain.
    Authors: Ibrahim Et al.
    Front Cell Neurosci  2018;12:453
  2. Analysis of Ins sensitivity in adipose tissue of patients with primary aldosteronism.
    Authors: Urbanet Et al.
    Purinergic Signal  2010;95:4037

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Eplerenone

There are currently no reviews for this product. Be the first to review Eplerenone and earn rewards!

Have you used Eplerenone?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.