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Eprosartan mesylate

Catalog #: 4696 Datasheet / COA / SDS

Discontinued Product

4696 has been discontinued.
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Eprosartan mesylate | CAS No. 144143-96-4 | Angiotensin AT1 Receptor Antagonists
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Description: Potent and selective AT1 receptor antagonist
Alternative Names: SK&F 108566

Chemical Name: (αE)-α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic acid methanesulfonate

Purity: ≥99%

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Biological Activity

Potent angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.5, 1.7, 3.9 and 9.2 nM at rat mesenteric artery, human liver membrane, human adrenal cortical membrne and rat adrenal cortical membrane respectively). Displays no effect on vasopressin or CGRP binding, or angiotensin-converting enzyme (ACE) activity. Inhibits the angiotensin II-induced pressor response in normotensive rats.

Technical Data

M.Wt:
520.62
Formula:
C23H24N2O4S.CH3SO3H
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
144143-96-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Angiotensin II inhibits Ins binding to endothelial cells.
    Oh et al.
    Diabetes Metab.J., 2011;35:243
  2. Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566.
    Edwards et al.
    J.Pharmacol.Exp.Ther., 1992;260:175

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