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ERGi-USU

Catalog #: 6632
1 Citation Datasheet / COA / SDS

Discontinued Product

6632 has been discontinued.
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ERGi-USU | CAS No. 1147-56-4 | Other Kinase Inhibitors
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Description: Rio2 kinase (RIOK2) inhibitor; inhibits ERG protein

Chemical Name: 1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ERGi-USU is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.

Technical Data

M.Wt:
255.3
Formula:
C13H9N3OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1147-56-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for ERGi-USU

The citations listed below are publications that use Tocris products. Selected citations for ERGi-USU include:

1 Citation: Showing 1 - 1

  1. Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer.
    Authors: Marc Et al.
    Elife  2021;10

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