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(±)-Eriodictyol

Catalog #: 7199 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7199/5
(±)-Eriodictyol | CAS No. 4049-38-1 | TRPV Inhibitors
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Description: Potent TRPV1 antagonist; also antioxidant; activates Nrf2/ARE signaling

Chemical Name: 2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one

Purity: ≥98%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(±)-Eriodictyol is a potent TRPV1 antagonist. Inhibits capsaicin (Cat. No. 0462) -induced Ca2+ influx in synaptosomes. Exhibits antinociceptive activity in animal models without affecting body temperature. Also antioxidant; protects against H2O2-induced neurotoxicity in vitro by activation of Nrf2/ARE signaling. Modeling studies predict binding to ACE2 preventing its interaction with SARS-CoV-2 S protein. Naturally-derived flavonoid. Orally bioavailable.

Technical Data

M.Wt:
288.26
Formula:
C15H12O6
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
4049-38-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
Although the natural (S)-enantiomer of Eriodictyol may be predominant, this molecule is prone to racemization in solution and will therefore be offered and displayed with undefined stereochemistry.

Background References

  1. Repurposing therapeutics for COVID-19: Supercomputer-based docking to the SARS-CoV-2 viral spike protein and viral spike protein-human ACE2 interface.
    Smith and Smith et al.
    ChemRxiv - Paper not yet peer reviewed, 2020;
  2. Eriodictyol: A flavonoid antagonist of the TRPV1 receptor with antioxidant activity.
    Rossato et al.
    Biochem.Pharmacol., 2011;81:544
  3. Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway.
    Lou et al.
    Neurochem.Int., 2012;61:251

Product Datasheets

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